这本书提供了关于放线菌生态学、多样性和应用的深入信息。这本书分为两大部分。第一部分讨论了放线菌的多样性、化学生物学和生态学。它还包括从土壤、内生和海洋来源的放线菌中发现天然产物。它包括天然产物发现、化学生物学、发现次生代谢物的新方法、天然产物的结构阐明和生物合成研究。这一部分的章节集中在分子水平上的生物和化学诱导对放线菌次级代谢的影响。本书的第二部分讨论了放线菌药物发现中的基因组和合成生物学方法。这一部分包括重点介绍代谢工程在优化天然产物合成方面的应用，以及组学数据在调节基因工程中的使用的章节。它涵盖了合成生物学和代谢工程的先进工具，包括集群组装、CRISPR/Cas9技术，以及放线菌天然产物过量生产的底盘菌株开发。它描述了利用生物信息学工具通过聚酮合成酶和非核糖体肽合成酶工程重新编程生物合成途径。这些先进的基因组和分子工具有望加速从放线菌中发现和开发具有医药和其他工业应用的新天然产物。这本书对微生物学、药学和药物发现领域的研究人员和学生很有用。
Natural Products from Actinomycetes: Diversity, Ecology and Drug Discovery
This book provides in-depth information about the ecology, diversity and applications of Actinomycetes. The book is divided into two major parts. The first part discusses the diversity, chemical biology and ecology of Actinomycetes. It also covers the discovery of natural products from soil, endophytic and marine-derived Actinomycetes. It includes natural product discovery, chemical biology, new methods for discovering secondary metabolites, structure elucidation and biosynthetic research of natural products. The chapters in this part focus on the effects of biological and chemical elicitation at molecular level on secondary metabolism in Actinomycetes. The second part of the book discusses genomic and synthetic biology approaches in Actinomycetes drug discovery. This part includes chapters focused on the application of metabolic engineering to optimize natural product synthesis and the use of omics data in engineering of regulatory genes. It covers the advanced tools of synthetic biology and metabolic engineering including cluster assembly, CRISPR/Cas9 technologies, and chassis strain development for natural product overproduction in Actinomycetes. It describes the use of bioinformatics tools for reprogramming of biosynthetic pathways through polyketide synthase and non-ribosomal peptide synthetase engineering. These advanced genomic and molecular tools are expected to accelerate the discovery and development of new natural products from Actinomycetes with medicinal and other industrial applications. The book is useful to researchers and students in the field of microbiology, pharmaceutical sciences and drug discovery.
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