这本书探索了最新的技术进步，涵盖了与精确医学有关的系统医学的所有方面。本书的章节分为四个部分。第一部分重点介绍了蛋白质组学在生物标志物识别、组学与表型数据整合、药物诱导史蒂文斯-约翰逊综合征的药物指导治疗方面的最新成就。第二部分包括基于系统的药物研究和药物开发计算方法、优化药物系统暴露的原则以及药物再利用的动物规则。第三部分介绍网络生物学、定量系统毒理学、建模和刺激患者反应变量的计算工具和方法。第四部分讨论系统医学如何解决未满足的医疗卫生需求，并确定教育需求。以分子生物学系列中非常成功的方法编写，各章包括对各自主题的介绍、必要材料和试剂的列表、循序渐进、易于复制的实验室协议，以及故障排除和避免已知陷阱的提示。
尖端和彻底的系统医学：方法和协议是科学界的宝贵资源，将帮助研究人员共同努力，进一步实现促进全球健康的目标。
Systems Medicine (Methods in Molecular Biology, 2486)
This volume explores the latest technological advances and covers all facets of systems medicine with respect to precision medicine. The chapters in this book are organized into four parts. Part One highlights the recent achievements in proteomics for biomarkers identification, integration of omics and phenotypic data for precision medicine, and medicine-guided treatment of drug-induced Stevens-Johnson syndrome. Part Two covers systems-based computational approaches for pharmaceutical research and drug development, the principle of optimizing systemic exposure of drugs, and Animal Rule for drug repurposing. Part Three looks at computational tools and methodologies of network biology, quantitative systems toxicology, and modeling and stimulating patient response variabilities. Part Four talks about how systems medicine can address unmet medical and health needs, and identify educational needs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, Systems Medicine: Methods and Protocols is a valuable resource for the scientific community that will help researchers work together toward the further advancement of achieving the goal of promoting global health.
OR
